• Associate Scientist

    Job Locations US-CA-South San Francisco
    Job ID
    Research & Development
  • Overview

    The Cell Biology Research group is seeking an independent and motivated Associate Scientist to join a research team focused on the discovery and development of novel therapeutics for neurodegenerative diseases. The qualified candidate must be scientifically driven and will participate in antibody discovery by aiding with the design, execution and reporting of preclinical cell biology studies.


    • Work within the Cell Biology group, as well as with additional preclinical teams, to investigate biological processes and to assess the mechanism of action of novel antibodies using a variety of techniques (flow cytometry, immunofluorescence, immunoblot, qPCR, etc.) with a willingness to learn additional techniques as needed
    • Perform well in handling multiple projects simultaneously
    • Establish and maintain cell lines and primary cell cultures
    • Develop novel cell-based screening assays
    • Use molecular biology, cell biology and imaging techniques to explore biology related to clinical, preclinical and discovery programs
    • Aid in the organization and supply of the Cell Biology labs
    • Communicate results in written summaries and internal oral presentations


    • The candidate must have a BS in biology or a related discipline and 10+ years of industry experience in cell biology or a related field
    • Previous experience with implementation of neurodegenerative cell based in vitro assays including flow cytometry and basic molecular biology techniques such as ELISA and western blots
    • Previous experience with immunohistochemistry and immunofluorescence a plus
    • Competency with basic cell culture techniques
    • Isolation of primary neuronal cells a plus
    • High content imaging experience a plus
    • Competencies and Attributes:

    • Demonstrated leadership ability to drive results that are needed to achieve the company objectives in accord with the Prothena core cultural values of courageous, creative, selfless, and joyful


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