• Scientist, Biochemistry

    Job Locations US-CA-South San Francisco
    Job ID
    Research & Development
  • Overview

    Be an integral part of a dynamic team developing novel therapeutics targeting pathogenic misfolded/aggregated proteins. Provide conceptual input and technical biochemistry expertise in the characterization of diverse protein targets. Provide innovative protein purification expertise with demonstrated proficiency in all standard bioprocess and chromatography techniques.  Be a creative problem-solver to independently resolve protein purification and characterization issues and to implement novel strategies to overcome production challenges.


    • Develop and implement purification strategies to isolate proteins and antibodies from natural and recombinant sources
    • Characterize the biophysical properties of isolated proteins (solubility, aggregation, purity, post-translational modifications) and how these properties affect protein structure and function.
    • Independently generate, analyze and critique experimental results and communicate findings to diverse audiences.


    • PhD with at least 5 years of relevant academic experience or BA/BS in Biochemistry or similar discipline with at least 10 years of industry experience demonstrating direct participation in preclinical research programs
    • Demonstrated expertise and proficiency in all standard bioprocess and chromatography techniques
    • Experience in the biophysical and analytical characterization of proteins, using state-of-the-art protein characterization techniques such as DLS, SPR, microcalorimetry, HPLC, and mass-spectroscopy
    • Tissue culture/cell biology experience a plus


    Competencies and Attributes:

    • Demonstrated leadership to drive results that are needed to achieve company objectives in accord with Prothena’s culture and core values – courageous, imaginative, selfless and joyful
    • Outstanding written, verbal, and problem-solving skills is essential.


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