• Director, In Vivo Pharmacology

    Job Locations US-CA-South San Francisco
    Job ID
    Research & Development
  • Overview

    We are seeking a highly motivated and scientifically rigorous individual to join our team as a Director of In Vivo Pharmacology.  The successful candidate is collaborative and team-oriented scientist with proven leadership abilities. The Director will lead a growing team responsible for in vivo studies to support a robust pipeline of immunotherapy approaches in a science- and patient-centric company. 


    • Provide leadership and oversight of the nonclinical in vivo Pharmacology group
    • Provide strategic, scientific and managerial leadership across functional research areas and program teams as the functional area representative
    • Design, manage, analyze, review, summarize, interpret and report results of in vivo pharmacology studies (primary and secondary pharmacology, mechanism of action, mechanism of disease, PK/PD, etc).
    • Initiate and manage relationships with contract research organizations and academic laboratories
    • Manage research collaborations
    • Develop, oversee, and manage department budget, liaising with the Head of Research and the Finance group
    • Provide input and tactical planning to nonclinical development strategy
    • Prepare reports, regulatory documents, INDs and BLAs. Ensures compliance with regulatory guidelines
    • Foster a collaborative, innovative and problem-solving culture


    • PhD in neurobiology, cell biology, pharmacology or related discipline
    • Minimum of 10 years of pharmaceutical/biotech industry experience in pharmacology departments
    • Previous supervisory/management experience leading more than 5 employees
    • Experience in immunotherapy and antibody development.
    • Proficiency in development and characterization of functional readouts to investigate novel mechanisms of action
    • Ability to synthesize and interpret diverse, multidisciplinary data sets
    • Demonstrated ability to identify, negotiate, and oversee outsourced services with vendors.
    • Experience with financial budget planning and tracking
    • Strong verbal and scientific writing skills, with experience preparing pharmacology sections for regulatory submissions.


    Competencies and Attributes:

    • Demonstrated leadership to drive results that are needed to achieve company objectives in accord with Prothena’s culture and values – courageous, imaginative, selfless and joyful


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